Latest Publications

1. Hernandez JOR, Wang X, Vazquez-Segoviano M, Lopez-Marfil M, Sobral-Reyes MF, Moran-Horowich A, Sundberg M, Lopez-Cantu DO, Probst CK, Ruiz-Esparza GU, Giannikou K, Abdi R, Henske EP, Kwiatkowski DJ, Sahin M, Lemos DR. A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo. Nat. Commun. 2021 Nov 11;12(1):6496.

2. Wang X, Liu Z, Sandoval-Salaiza DA, Afewerki S, Jimenez-Rodriguez MG, Sanchez-Melgar L, Güemes-Aguilar G, Gonzalez-Sanchez DG, Noble O, Lerma C, Parra-Saldivar R, Lemos DR, Llamas-Esperon GA, Shi J, Li L, Lobo AO, Fuentes-Baldemar AA, Bonventre JV, Dong N, Ruiz-Esparza GU. Nanostructured Non-Newtonian Drug Delivery Barrier Prevents Postoperative Intrapericardial Adhesions. ACS Appl Mater Interfaces. 2021 Jun 30;13(25):29231-29246.

3. Li L, Galichon P, Xiao X, Figueroa-Ramirez AC, Tamayo D, Lee JJ, Kalocsay M, Gonzalez-Sanchez D, Chancay MS, McCracken KW, Lee NN, Ichimura T, Mori Y, Valerius MT, Wilflingseder J, Lemos DR, Edelman ER, Bonventre JV. Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Rep. 2021 Jun 4;22(6):e51169.

4. Moran-Horowich A, Lemos DR. Methods for the Study of Renal Fibrosis in Human Pluripotent Stem Cell-Derived Kidney Organoids. Methods Mol Biol. 2021;2299:435-445.

5. Li X, Zhao J, Kasinath V, Uehara M, Jiang L, Banouni N, McGrath MM, Ichimura T, Fiorina P, Lemos DR, Shin SR, Ware CF, Bromberg JS, Abdi R. Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation. J Clin Invest. 2020 Aug 3;130(8):4182-4194.

6. Soliman H, Paylor B, Scott RW, Lemos DR, Chang C, Arostegui M, Low M, Lee C, Fiore D, Braghetta P, Pospichalova V, Barkauskas CE, Korinek V, Rampazzo A, MacLeod K, Underhill TM, Rossi FMV. Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors. Cell Stem Cell. 2020 Feb 6;26(2):205-220.e8. 

7. Sobral-Reyes MF, Lemos DR. Recapitulating human tissue damage, repair, and fibrosis with human pluripotent stem cell-derived organoids. Stem Cells. 2020 Mar;38(3):318-329.

8. Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS. Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. J Am Soc Nephrol. 2018 Jun;29(6):1690-1705.

9. Yu KH, Miron O, Palmer N, Lemos DR, Fox K, Kou SC, Sahin M, Kohane IS. Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex. Neurology. 2018 Nov 20;91(21):974-976.

10. Lemos DR, Duffield JS. Tissue-resident mesenchymal stromal cells: implications for tissue-specific anti-fibrotic therapies. Science Trans. Med. 2018 Jan 31;10(426). pii: eaan5174. doi: 10.1126/scitranslmed.aan5174.

11. Lemos DR, Campanholle G., Aburatani T., Gomez I., Sheng Y., Chen D., Ligresti G.,  Dang L., Marsh G., Huang A., Duffield J.S. Maintenance of vascular integrity by pericytes is essential for normal kidney function. Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1230-F1242.PMID: 27335372.

12. Fiore D., Judson R. N., Low M., Lee S., Zhang E., Hopkins C., Xu P., Lenzi A., Rossi F.M.V.,
Lemos DR. Pharmacological blockage of fibro/adipogenic progenitor expansion is associated with impaired skeletal muscle regeneration. Stem Cell Res. 2016 Jul;17(1):161-9. PMID: 27376715.

13. Lemos DR, Babaeijandaghi F., Low M., Chang C, Lee S.T., Fiore D, Zhang R-H, Natarajan A., Nedospasov S.A., Rossi F.M.V. Nilotinib reduces muscle fibrosis in mdx mice by promoting Tnf-mediated apoptosis of fibro/adipogenic progenitors. Nat. Med. 2015 Jul;21(7):786-94. PMID: 26053624.

Commented in:

 News and Views. Tidball J.G. and Wehling-Henricks M Shifts in macrophage
cytokine production drive muscle fibrosis. Nat. Med. 2015 Jul;21(7):665-6.
PMID: 26151325.
 Spotlight. Muñoz-Canoves P. and Serrano A. Macrophages decide between
regeneration and fibrosis in muscle. Trends Endocrinol. Metabol. 2015
Sep;26(9):449-50. PMID: 26250053.